DENVER, CO, March 20, 2026 (GLOBE NEWSWIRE) — The International Down Syndrome Basis (GLOBAL) is proud to announce that the Company for Healthcare Analysis and High quality (AHRQ) systemic evaluate of the brand new version of the GLOBAL Medical Care Tips for Adults with Down Syndrome (GLOBAL Grownup Guideline) has been revealed at present within the prestigious Efficient Well being Care (EHC) Database.
This is a vital milestone within the 5-to-7-year rigorous growth course of required to publish skilled, evidence-based medical tips. The ECH publication consists of up to date findings on prevalence and therapy for frequent co-occurring situations and paves the best way for the Second Version of the GLOBAL Grownup Guideline, which ought to be finalized by the top of 2026 or early 2027. The brand new version updates and expands the primary version, which was revealed in JAMA in 2020 and established the primary evidence-based requirements for the grownup Down syndrome group. The JAMA publication was one of the vital visited medical advice pages on the JAMA web site and to this point has been professionally referenced over 200 occasions.
“To have the ability to announce this in time for World Down Syndrome Day is especially significant, stated GLOBAL Vice President of Analysis and Medical Care Bryn Gelaro. “This publication, led by PICORI and AHRQ, is a powerful validation of the rigor we bring to Down syndrome research and medical care. By vetting clinical expertise against hard evidence, we are finally providing a reliable resource for medical professionals to ensure adults with Down syndrome receive the specialized, high-quality care they deserve.”
In 2023, GLOBAL was awarded a competitive grant from the Patient-Centered Outcomes Research Institute (PCORI). This grant funded a milestone systematic review designed to answer the GLOBAL Adult Guideline authors’ critical health questions and synthesize clinical expertise and research evidence. To ensure the highest level of objectivity, the AHRQ—the federal agency tasked with improving the safety and quality of America’s healthcare system—was commissioned to lead the comprehensive review of the literature.
The quality of the AHRQ review manuscript earned immediate publication in the EHC Database. In addition, the publication was acknowledged as a vital contribution to national health standards by the Director of AHRQ at the U.S. Department of Health and Human Services (HHS), Roger D. Klein, MD, JD.
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“The GLOBAL Adult Guideline is important to my life,” says 2026 GLOBAL Ambassador Letizia Napoleone. “When I go to the doctor, I want to get better! They need to know about Down syndrome. I am proud to be part of GLOBAL who is helping doctors understand how to support people with Down syndrome to have healthy long lives.”
“We are deeply grateful to donors – including Key Collaborators and GLOBAL Member Organizations who understand the importance of this resource and have committed funds in support updates and the addition of important new medical cares,” says GLOBAL President & CEO Michelle Sie Whitten. Additionally it is a testomony to Bryn Gelaro and David Tolleson who’ve labored so diligently to make sure that the Guideline Workgroup can proceed the advanced job of rigorous evaluate, wonderful writing, and publication. As a mother to Sophia, it’s fantastic to know that she is going to get infinitely higher care in her previous age due to this useful resource.”
The AHRQ systematic evaluate will straight inform the 2nd Version GLOBAL Grownup Tips. Whereas the primary version addressed 9 essential areas— Conduct, Alzheimer’s/Dementia, Diabetes, Heart problems, Weight problems, Osteoporosis, Atlantoaxial Instability, Thyroid Illness, and Celiac Illness, and Thyroid Issues—the brand new version will construct on that basis to incorporate 5 extra matters:
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Blood CancersSolid Tumor (Cancers)Sleep Apnea Eye and VisionMusculoskeletal
“Our household is honored to help the GLOBAL Medical Care Tips for Adults with Down Syndrome,” says Michele Ritter, a long-time GLOBAL supporter. “Having lost my beautiful sister Lorraine to Alzheimer’s, we know firsthand the gaps in medical care for adults with Down syndrome. We are proud and excited to support the 2nd edition and to see the impact these guidelines will have on the health and longevity of our loved ones around the world.”
Fifty-four GLOBAL Member Organizations have supported the 2nd Edition GLOBAL Adult Guideline. One of the largest multi-year donors, the Down Syndrome Alliance of the Midlands (DSA), based in Omaha, Nebraska, is grateful for GLOBAL’s efforts to establish this first-in-kind resource.
“For our families in the Midlands, these guidelines are more than just research—they are a lifeline,” said DSA Executive Director Elizabeth Draney. “It is great to have federal support but equally important, the GLOBAL Adult Guideline is something that doctors in our community trust and can help ensure our adult with Down syndrome receive the best care possible. We pledged our support for the second edition because investing in the guideline is an investment in the health of every person with Down syndrome.”
In 2018 GLOBAL efficiently lobbied and advocated for the primary trans-Nationwide Institutes of Well being Down syndrome funding program referred to as the INCLUDE Challenge. Within the time for the reason that first version of the GLOBAL Grownup Guideline was revealed, the NIH INCLUDE Challenge has supplied over $440M of funding to Down syndrome analysis that’s contributing to the proof that’s the very basis of the rules. As well as, the INCLUDE Challenge analysis is bolstering the proof that contributes to the GLOBAL Grownup Guideline evidenced by the 2nd Version having 300% extra high quality publications to attract from.
Record of GLOBAL Grownup Guideline Authors: Medical Director at College of Pittsburgh Grownup Down Syndrome Middle, Peter Bulova (MD), Medical Director of the Down Syndrome Clinic and Analysis Middle at Kennedy Kreiger, George Capone (MD), Medical Director and Co-Founder, Advocate Medical Group Grownup Down Syndrome Middle in Chicago, Brian Chicoine (MD), Government Director of the Linda Crnic Institute for Down Syndrome at College of Colorado Anschutz Medical Campus, Aurora, CO Joaquín Espinosa(PhD), Medical Director of Immunogenetics and Transplantation Laboratory on the College of Arkansas for Medical Sciences, Terry Harville (MD), Surgical Director of the Advanced Obstructive Sleep Apnea Middle on the College of Cincinnati, Christine Heubi (MD), Assistant Professor within the Division of Bodily Remedy on the College of Nevada, Thessa Hilgenkamp (PhD), Professor of Ophthalmology on the College of Pittsburgh Faculty of Drugs, Vishal Jhanji (MD), Medical Director, Grownup Down Syndrome Clinic at Denver Well being, Barry Martin, MD, Chief of Pediatric Ophthalmology at Youngsters’s Hospital Colorado, Emily McCourt (MD), Director of the Down Syndrome Behavioral Well being Collaborative, College of Colorado Faculty of Drugs Lina Patel (PsyD), Co-founder of the Adults with Down Syndrome Specialty Clinic on the College of Kansas Medical Middle, Moya Peterson (PhD, ARNP), Director of Medical Pupil Schooling, College of Colorado Anschutz Medical Campus, Michael Puente Jr (MD), Medical Director of the Alzheimer’s Therapeutic Analysis Institute and Alzheimer’s Scientific Trials Consortium – Down Syndrome Principal Investigator at Keck Faculty of Drugs of College of Southern California, Michael Rafii (MD, PhD), Professor of Household and Neighborhood Drugs at Cleveland Clinic Lerner School of Drugs and Case Western Reserve College Faculty of Drugs Carl Tyler (MD), and Supplier on the Down Syndrome Middle of Western PA and Medical Director of Avenue Drugs Pitt on the College of Pittsburgh Medical Middle, Anna Marie White (MD).
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To study extra concerning the GLOBAL Medical Care Tips for Adults with Down Syndrome go to https://www.globaldownsyndrome.org/medical-care-guidelines-for-adults/.
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Concerning the International Down Syndrome FoundationThe International Down Syndrome Basis (GLOBAL) is the most important non-profit within the U.S. working to avoid wasting lives and dramatically enhance well being outcomes for individuals with Down syndrome. GLOBAL established the primary Down syndrome analysis institute and helps over 400 scientists and over 2,700 sufferers with Down syndrome from 40 states and 11 nations. Working carefully with Congress and the Nationwide Institutes of Well being, GLOBAL is the lead advocacy group within the U.S. for Down syndrome analysis and care. GLOBAL has a membership of over 130 Down syndrome organizations worldwide, and is a part of a community of Associates – the Crnic Institute for Down Syndrome, the Sie Middle for Down Syndrome, the College of Colorado Alzheimer’s and Cognition Middle – all on the Anschutz Medical Campus, and the GLOBAL Grownup Down Syndrome Clinic at Denver Well being.
GLOBAL’s broadly circulated medical publications embody International Medical Care Tips for Adults with Down Syndrome, Prenatal & New child Down Syndrome Data, and the award-winning journal Down Syndrome World TM. GLOBAL additionally organizes the annual AcceptAbility Gala in Washington DC, andthe annual Be Lovely Be Your self Trend Present, the most important Down syndrome fundraiser on the planet. Go to globaldownsyndrome.org and observe us on social media Fb, X, Instagram, LinkedIn, and YouTube.
GLOBAL Medical Care Tips for Adults with Down Syndrome (GLOBAL Grownup Guideline)
GLOBAL Medical Care Tips for Adults with Down Syndrome (GLOBAL Grownup Guideline)
