CAMBRIDGE, UK — April 21, 2026 — Panakeia (“the Company”), the world’s first in silico multi-omics firm, at this time unveiled landmark pathway activation information in cancers on the American Affiliation for Most cancers Analysis (AACR) Annual Assembly 2026, additional proving its distinctive functionality to unlock full organic blueprints important for drug discovery and medical decision-making.
The Firm revealed that its PANProfiler platform efficiently determines purposeful metabolic hallmarks—the important pathways that gasoline most cancers progress—instantly from routine brightfield pictures. This information, constructing on findings offered earlier within the week, demonstrates that the PANProfiler platform can establish purposeful organic states that drive affected person response, revealing cases the place sufferers could not reply to remedy regardless of having a constructive biomarker standing or expression of a drug goal. In contrast to present trade efforts that stay on the degree of speculation, Panakeia is actively proving the organic foundation of those insights, shifting past binary outcomes to offer a “functional blueprint.” By uncovering these organic blueprints that may in any other case require a number of, disparate wet-lab experiments to correlate, the PANProfiler platform establishes a brand new commonplace for the sector, changing the restrictions of conventional testing to enhance the accuracy of affected person choice and, in the end, affected person outcomes.
Metabolic reprogramming is a acknowledged hallmark of most cancers but dependable evaluation of a tumor’s metabolic state stays a major problem as a result of reliance on specialised workflows, recent tissue necessities, and excessive prices. The PANProfiler platform overcomes this “assessment gap” by analyzing the biology of cells and tissues to ship an entire organic blueprint. As a result of this course of is non-destructive, it preserves beneficial samples whereas accelerating drug discovery and elevating the precision of medical decision-making.
Examine Highlights and Medical Relevance:
Unprecedented Scope: The research evaluated 450 pathway-cancer fashions throughout 21 completely different most cancers sorts, using information from The Most cancers Genome Atlas (TCGA).Sturdy Dedication: Outcomes exhibit that 87% of the metabolic pathway fashions have been profitable in figuring out exercise from routine pictures, with 9% displaying significantly sturdy efficiency (AUC > 0.65).Actionable Therapeutic Insights: The platform demonstrated a constant means to find out exercise in key pathways which can be present therapeutic targets, together with constant Nucleotide Metabolism, Nuclear Transport (XPO1), and Fatty Acid beta-oxidation enrichment throughout a number of cancers.Scalable Stratification: By figuring out these purposeful states from the routine picture alone, Panakeia gives a non-destructive complement to conventional molecular profiling, paving the way in which for biomarker-driven trial enrichment at scale.
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Pahini Pandya, Chief Govt Officer and Founder at Panakeia, commented: “Our presence at AACR this year marks a pivotal step in our mission to unlock complete biology at scale, providing a new level of biological resolution that allows biopharma partners to identify novel targets and accelerate the development of precision therapies while simultaneously making the highest standard of precision medicine accessible to patients and doctors worldwide. By determining these functional metabolic states directly from routine images of tissues and cells, we are ensuring both drug developers and clinicians have the tools to reduce failure rates and improve patient outcomes across the entire life cycle of a drug and the patient journey respectively.
“Panakeia’s technology enables us to uncover biological truths—such as the unexpected disagreement between clinical status and actual pathway activation seen in our HER2 study—that remain invisible to the human eye and traditional testing. By grounding our AI in a biology-first approach, we are unlocking the insights necessary to transform the future of healthcare and drug discovery, making precision diagnostics a global reality.”
Regulatory-approved medical merchandise leveraging Panakeia’s know-how are already deployed in hospitals globally. This deployment is supported by rigorous impartial validation, as the corporate continues to set the gold commonplace in healthcare AI by means of ongoing work with regulatory our bodies, together with the MHRA and FDA.
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Presentation Particulars:
Oral Presentation:
Session: Minisymposium: Machine Studying Approaches for Most cancers Prognosis and Remedy PredictionPresentation Title: A translational deep studying platform determines metabolic pathway exercise from routine H&E slides to allow affected person stratificationPresenter: Dr. Pahini PandyaTime: April 21, 2026, 2:30 PM – 4:30 PM PSTLocation: Ballroom 20 CD – Higher Degree – San Diego Conference Heart
Poster Presentation (Introduced April 19):
Poster Title: Practical pathway evaluation reveals discordance between medical HER2 standing and downstream effector activation in breast cancerSession Title: Utility of Bioinformatics to Most cancers Biology 1Location: Poster Part 3, Board Quantity 19
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About Panakeia Panakeia is the world’s first in silico multi-omics firm, constructing AI options to uncover full biology at scale and speed up precision medication analysis, drug discovery, growth and medical decision-making. Panakeia’s PANProfiler platform makes use of a biology-first AI method to find out biomarker standing throughout DNA, RNA, proteins, and metabolites instantly from routinely used brightfield pictures of tissues and cells.
The PANProfiler platform has been independently validated in peer-reviewed publications, together with Nature Communications Medication, the place it was recognised as one of many journal’s prime 25 papers of 2024. Two UKCA-marked medical merchandise derived from the platform are deployed in hospitals, enabling sooner and extra accessible precision diagnostics.
To study extra about Panakeia’s platform go to: https://www.panakeia.ai/
